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voluntary reports of adverse events in patients taking immediate-release paroxetine hydrochloride that have been received since market introduction and not listed above that may have no causal relationship with the drug include acute pancreatitis, elevated liver function tests the most severe cases were deaths due to liver necrosis, and grossly elevated transaminases associated with severe liver dysfunction , guillain-barr syndrome, stevens-johnson syndrome, toxic epidermal necrolysis, priapism, syndrome of inappropriate adh secretion, symptoms suggestive of prolactinemia and galactorrhea; extrapyramidal symptoms which have included akathisia, bradykinesia, cogwheel rigidity, dystonia, hypertonia, oculogyric crisis which has been associated with concomitant use of pimozide; tremor and trismus; status epilepticus, acute renal failure, pulmonary hypertension, allergic alveolitis, anaphylaxis, eclampsia, laryngismus, optic neuritis, porphyria, restless legs syndrome rls , ventricular fibrillation, ventricular tachycardia including torsade de pointes , thrombocytopenia, hemolytic anemia, events related to impaired hematopoiesis including aplastic anemia, pancytopenia, bone marrow aplasia, and agranulocytosis , vasculitic syndromes such as henoch-sch nlein purpura and premature births in pregnant women.

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paroxetine is a category d drug during pregnancy ie, human studies have shown a risk to the fetus, but the drug s benefits may outweigh the risk in pregnant women .

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a study of outpatients with major depressive disorder who had responded to paroxetine tablets hdrs total score 8 during an initial 8-week open-treatment phase and were then randomized to continuation on paroxetine tablets or placebo for 1 year demonstrated a significantly lower relapse rate for patients taking paroxetine tablets 15 compared to those on placebo 39 .

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i am also stop taking paroxetine 20mg after one year by myself cause i felt physically really sick from it, my kidneys went mad, sleeping 17 hours without any reason etc , the cold turkey way and yes, i feel them too.


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